Managing digital assets across multiple blockchains has become essential for modern crypto users. With the growing complexity of decentralized finance (DeFi), NFTs, and multi-chain ecosystems, having a secure and versatile wallet is no longer optional — it's a necessity. One of the most trusted ways to secure your private keys is through Ledger hardware wallets, which store them offline and protect against online threats.
This guide explores the 10 best cross-chain wallets with Ledger support, offering seamless integration, robust security, and access to DeFi, staking, and decentralized applications (DApps). Whether you're new to crypto or an experienced investor, these wallets combine convenience with military-grade protection.
Why Use a Cross-Chain Wallet With Ledger?
Cross-chain wallets allow users to interact with multiple blockchains from a single interface. When paired with Ledger’s hardware security, they offer:
- Offline private key storage – immune to online hacks.
- Non-custodial control – you own your assets.
- Multi-chain DeFi access – swap, stake, and trade across networks.
- User privacy – minimal KYC requirements across most platforms.
These features make Ledger-integrated wallets ideal for managing diverse portfolios securely.
👉 Discover how secure wallet integration can protect your crypto journey.
1. Hana Wallet
Hana Wallet stands out as a powerful multi-chain DeFi wallet with full Ledger support. It seamlessly connects to both the ICON blockchain and EVM-compatible chains, making it ideal for users navigating heterogeneous ecosystems.
Its non-custodial design ensures that users retain full control while interacting with DeFi protocols, swapping tokens, or managing staked assets. The integration with Ledger enhances security without sacrificing usability.
Key Features:
- Ledger Support: Yes – private keys stored securely offline.
- Cross-Chain Compatibility: ICON and EVM chains (e.g., Ethereum, BSC, Polygon).
- Security: End-to-end encryption and user-controlled keys.
- DeFi Access: Direct interaction with decentralized exchanges and yield farms.
- Staking Support: Earn passive income on supported tokens.
Hana is particularly useful for those invested in the ICON ecosystem who also want flexibility across Ethereum-compatible networks.
2. DeFi Wallet
DeFi Wallet offers a streamlined experience for users seeking secure access to decentralized finance. With native Ledger integration, it ensures that private keys never leave the hardware device during transactions.
The wallet supports multiple blockchains and allows direct participation in staking and liquidity pools — all within a clean, intuitive interface.
Key Features:
- Ledger Support: Yes – secure signing via hardware wallet.
- Cross-Chain Compatibility: Multiple chains optimized for DeFi use.
- Asset Management: Unified dashboard for tracking balances across chains.
- Staking Support: Built-in staking with reward tracking.
- Privacy-Focused: No mandatory KYC procedures.
This wallet is perfect for active DeFi participants who prioritize security and ease of use.
3. MyEtherWallet (MEW)
MyEtherWallet (MEW) remains one of the most trusted names in Ethereum-based wallets. While originally designed for ETH and ERC-20 tokens, MEW now supports various EVM-compatible Layer 2 networks, expanding its cross-chain utility.
With full Ledger compatibility, MEW lets users sign transactions securely while maintaining complete control over their funds.
Key Features:
- Ledger Support: Yes – hardware-integrated transaction signing.
- Cross-Chain Compatibility: Ethereum and EVM chains (Arbitrum, Optimism, etc.).
- DeFi Access: Integrated DApp browser for NFTs, swaps, and lending platforms.
- Staking Support: Participate in Ethereum 2.0 staking directly from the wallet.
- Open Source: Transparent codebase enhances trust.
👉 Learn how hardware-backed security elevates your DeFi experience.
MEW is ideal for Ethereum enthusiasts looking for a secure gateway into DeFi and Web3.
4. Zerion
Zerion is more than just a wallet — it's a DeFi portfolio manager with full Ledger support. It aggregates assets across multiple chains into one dashboard, allowing users to track performance, swap tokens, and invest in yield strategies — all without giving up custody.
Its sleek interface and advanced analytics cater to both beginners and sophisticated investors.
Key Features:
- Ledger Support: Yes – secure transaction approval via Ledger.
- Cross-Chain Compatibility: Ethereum, Polygon, Arbitrum, Optimism, and more.
- Portfolio Tracking: Real-time P&L, asset distribution, and historical data.
- Token Swaps: Aggregated best rates across decentralized exchanges.
- Non-Custodial: Full user control at all times.
Zerion excels at simplifying complex multi-chain investing into a single, intuitive platform.
5. MetaMask
MetaMask continues to be the most widely used crypto wallet, especially among DeFi users. Its browser extension and mobile app support Ethereum and all EVM-compatible chains, making it inherently cross-chain.
When connected to a Ledger device, MetaMask leverages the hardware wallet’s security while providing access to thousands of DApps.
Key Features:
- Ledger Support: Yes – via USB or Bluetooth pairing.
- Cross-Chain Compatibility: Ethereum, Binance Smart Chain, Polygon, Avalanche, etc.
- DApp Browser: Seamless access to NFT markets, DeFi protocols, and games.
- Token Swaps: In-wallet swaps powered by aggregators.
- Community Trust: Over a decade of development and widespread adoption.
MetaMask is the go-to choice for anyone entering the Web3 space.
6. Paradex
Paradex functions as both a decentralized exchange (DEX) and a cross-chain wallet with native Ledger support. It enables peer-to-peer trading without requiring users to deposit funds into custodial accounts.
Transactions are signed securely using Ledger devices, ensuring that assets remain under user control at all times.
Key Features:
- Ledger Support: Yes – secure order signing.
- Cross-Chain Trading: Swap assets across different blockchains.
- Non-Custodial Model: Users retain ownership throughout trades.
- Low Fees: Optimized routing reduces slippage and gas costs.
Paradex is ideal for traders who value autonomy and security in decentralized markets.
7. Guarda Wallet
Guarda Wallet supports over 50 blockchains and integrates with Ledger for maximum security. As a non-custodial solution, it allows users to manage Bitcoin, Ethereum, Binance Chain, and many others from one interface.
It also includes built-in staking and token exchange features.
Key Features:
- Ledger Support: Yes – hardware-backed transactions.
- Cross-Chain Compatibility: Broad support including BTC, ETH, BSC, TRON, and more.
- Staking Support: Stake multiple coins directly in-app.
- Exchange Functionality: Swap tokens without leaving the wallet.
Guarda is excellent for multi-asset holders seeking an all-in-one solution.
8. MyEOSWallet
Designed specifically for the EOS network, MyEOSWallet offers seamless Ledger integration for secure management of EOS tokens and NEP-5 assets.
It supports staking, voting, and dApp interactions — crucial features for active EOS participants.
Key Features:
- Ledger Support: Yes – secure key handling.
- EOS Focus: Optimized for EOS blockchain operations.
- Governance Participation: Vote on proposals directly from the wallet.
- User-Friendly Interface: Simple navigation even for newcomers.
Perfect for EOS ecosystem members wanting hardware-grade security.
9. Firefly Wallet
Firefly is the official wallet for the IOTA network, supporting Ledger integration for secure IOTA token management. It enables staking-like participation through network validation (via Coordicide).
Though focused on IOTA, it offers limited cross-chain capabilities.
Key Features:
- Ledger Support: Yes – offline key storage.
- IOTA Ecosystem: Full support for Tangle-based transactions.
- Staking Support: Participate in network consensus rewards.
- Lightweight Design: Fast syncing and low resource usage.
Best suited for IOTA investors and developers.
10. Neon Wallet
Neon Wallet is the premier choice for NEO blockchain users. With Ledger support, it secures NEO and NEP-5 tokens while enabling access to dApps and staking rewards.
Key Features:
- Ledger Support: Yes – hardware-integrated security.
- NEO Blockchain: Full functionality for NEO ecosystem.
- Staking Support: Earn GAS rewards through token holding.
- DeFi Access: Connects to NEO-based decentralized applications.
Ideal for long-term supporters of the NEO platform.
Frequently Asked Questions (FAQ)
Q: What does Ledger support mean in a crypto wallet?
A: Ledger support means the wallet can connect to a Ledger hardware device to sign transactions securely. Your private keys never leave the Ledger, protecting against online threats.
Q: Are these wallets truly non-custodial?
A: Yes — all listed wallets are non-custodial. You retain full control of your private keys when used with Ledger.
Q: Can I use these wallets on mobile?
A: Most — including MetaMask, Zerion, Guarda, and Neon — offer mobile apps compatible with Ledger via Bluetooth or USB adapters.
Q: Do I need technical knowledge to use these wallets?
A: Not necessarily. While some features may require learning, most have intuitive interfaces designed for ease of use.
Q: Which wallet supports the most blockchains?
A: Guarda Wallet and MetaMask lead in blockchain diversity, supporting dozens of EVM and non-EVM chains.
Q: Is there any risk using third-party wallet interfaces with Ledger?
A: As long as you download official versions from trusted sources, risks are minimal. Always verify URLs and app authenticity.
👉 Secure your multi-chain portfolio today with advanced wallet tools.